Isolated rat hepatocyte metabolism is affected by chronic renal failure

Cholesterol metabolism in rat is affected by protocatechuic acid.

The effects of protocatechuic acid on serum cholesterol and gene expression related to cholesterol metabolism in rats were investigated. Rats were fed a cholesterol-free diet with or without 5 g protocatechuic acid/kg diet for 4 wk. There were no significant differences in body weight and food intake among groups through the experimental period. The liver weight in the protocatechuic acid group...

Creatinine metabolism in chronic renal failure.

1. Creatinine metabolism was studied in nine patients with severe chronic renal failure who were nevertheless in a nearly steady state with respect to their creatinine pool. Labelled creatinine was injected intravenously and the specific radioactivity of creatinine in urine was measured during the ensuing 5-7 days. 2. In each patient, the decline in specific radioactivity with time was a single...

Abnormal Carbohydrate Metabolism in Chronic Renal Failure

as compared to controls (P < 0.05 for each). Alanine utilization for gluconeogenesis was increased from 40.2 ±3.86 gmol/min in control subjects to 143+39.0 ,umol/min in azotemic patients (P < 0.05). The percent of alanine utilization accounted for by gluconeogenesis was not altered in chronic renal insufficiency. In nondiabetic azotemic subjects, mean fasting glucose and Dr. Garber is an invest...

Urea metabolism in chronic renal failure.

Urea degradation was measured during 16 experiments in 13 chronic uremic patients being treated with essential amino acids or their analogues. [(14)C]Urea was injected i.v. and the clearance of labeled urea from its volume of distribution was compared with the simultaneous renal clearance of ordinary urea, which averaged 2.0 liters/day. The difference, extrarenal clearance of urea, averaged 3.1...

hepatitis c, chronic renal failure, control is possible!